From Pontiac, Rochester, and the North:
I-75 southbound to I-375, to Jefferson Avenue westbound; turn right (north) onto Griswold St.
From Clinton Township, St. Clair Shores, and the East:
I-94 westbound to I-75 south, to Jefferson Avenue westbound; turn right (north) onto Griswold St.
From Ann Arbor, Metro Airport, and the West:
I-94 eastbound to I-75 south, to I-375 to Jefferson Avenue westbound; turn right (north) onto Griswold St.
From Canada:
Via the Detroit-Windsor Tunnel, make a Michigan (bouldvard) left hand turn at Jefferson Avenue; turn right (north) onto Griswold St. Via the Ambassador Bridge, take I-75 North to I-375, to Jefferson Avenue westbound; turn right (north) onto Griswold St.